Eosinophils in Helminth Infection: Defenders and Dupes

The role of eosinophils and neutrophils in helminth-induced keratitis.

PURPOSE Intrastromal injection of mice with antigens from the parasitic helminth that causes river blindness (Onchocerca volvulus) induces eosinophil recruitment to the corneal stroma at the time of maximum corneal opacification and neovascularization. The present study was conducted to examine the role of eosinophils and neutrophils in onchocercal keratitis in control C57Bl/6 mice and in inter...

The enigmatic eosinophil: investigation of the biological role of eosinophils in parasitic helminth infection.

In many helminth infected hosts the number of eosinophils increases dramatically, often without any concurrent increases in the number of other leukocytes, so that eosinophils become the dominant cell type. Many experimental investigations have shown that the eosinophilia is induced by interleukin-5 (IL-5) but its functional significance remains unclear. Mice genetically deficient in IL-5 (IL-5...

Immunosuppression in Helminth Infection

1.1 Parasitism Parasitism is an antagonistic relationship between organisms of different species where the parasite benefits at the expense of the host. Helminths are long-living, multicellular parasites. There are two major phylla of helminths; Nematodes and Platyhelminthes. The nematodes contain the intestinal worms known as soil-transmitted helminths including hookworms, whipworms and the fi...

Chronic Helminth Infection Reduces

Helminth infection–induced malignancy

1 Department of Microbiology, Immunology and Tropical Medicine, School of Medicine & Health Sciences, The George Washington University, Washington DC, United States of America, 2 Research Center for Neglected Tropical Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington DC, United States of America, 3 Centre for Biodiscovery and Molecular Devel...